Recombinant APC Monoclonal Antibody
Product Specifications
Background
This gene encodes a tumor suppressor protein that acts as an antagonist of the Wnt signaling pathway. It is also involved in other processes including cell migration and adhesion, transcriptional activation, and apoptosis. Defects in this gene cause familial adenomatous polyposis (FAP), an autosomal dominant pre-malignant disease that usually progresses to malignancy. Disease-associated mutations tend to be clustered in a small region designated the mutation cluster region (MCR) and result in a truncated protein product.
Abbreviation
APC
UniProt
P25054
Host
Rabbit
Reactivity
Human
Immunogen
A synthetic peptide of human APC
Target
Adenomatous Polyposis Coli; Adenomatous polyposis coli protein; Apc; APC; CC1; Deleted in polyposis 2.5; DP2; DP2.5; DP3; FAP; FPC; GS; Protein APC
Clonality
Monoclonal
Clone
R06-2E4
Conjugation
Unconjugated
Applications
WB
Field of Research
Cancer; Cell Biology; Cardiovascular; Epigenetics and Nuclear Signaling; Neuroscience; Stem Cells
Purification
Affinity Purified
Concentration
300 μg/mL
Dilution
WB 1:500-1:1000
Buffer
50mM Tris-Glycine (pH 7.4), 0.15M NaCl, 40% Glycerol, 0.01% Sodium azide and 0.05% protective protein
Shipping Conditions
The product is shipped with ice pack, upon receipt, store it immediately at the temperature recommended.
Storage Conditions
Store at -20°C Valid for 12 months. Avoid freeze / thaw cycles.
Calculated Molecular Weight
312kDa
Observed Molecular Weight
160kDa
Isotype
IgG
Available Sizes
Documents
Curated Selection
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