Recombinant Angiotensin II Type 1 Receptor Monoclonal Antibody
Product Specifications
Background
Angiotensin II (Ang II), the main effector molecule of the renin-angiotensin system, exerts its actions mainly via interaction with type-1 angiotensin II receptor (AGTR1, also named as AT1R), thereby contributing to blood pressure regulation. AGTR1 mediates its action by association with G proteins that activate a phosphatidylinositol-calcium second messenger system. By regulating vascular tone, cardiovascular function, salt and water homeostasis, AGTR1 exerts an indispensable physiological role . AGTR1 has been implicated in diverse aspects of human disease, from the regulation of blood pressure and cardiovascular homeostasis to cancer progression .
Abbreviation
Angiotensin II Type 1 Receptor
UniProt
P30556
Host
Rabbit
Reactivity
Human
Immunogen
A synthetic peptide of human Angiotensin II Type 1 Receptor
Target
AGTR1; AG2S; AGTR1B; AT1; AT1AR; AT1B; AT1BR; AT1R; AT2R1; HAT1R
Clonality
Monoclonal
Clone
R07-1I6
Conjugation
Unconjugated
Applications
WB
Field of Research
Cancer; Cardiovascular; Metabolism
Purification
Affinity Purified
Concentration
300 μg/mL
Dilution
WB 1:1000-1:2000
Buffer
50mM Tris-Glycine (pH 7.4), 0.15M NaCl, 40% Glycerol, 0.01% Sodium azide and 0.05% protective protein
Shipping Conditions
The product is shipped with ice pack, upon receipt, store it immediately at the temperature recommended.
Storage Conditions
Store at -20°C Valid for 12 months. Avoid freeze / thaw cycles.
Calculated Molecular Weight
41kDa
Observed Molecular Weight
41kDa
Isotype
IgG
Available Sizes
Documents
Curated Selection
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