Recombinant Alkaline Phosphatase Monoclonal Antibody
Product Specifications
Background
There are at least four distinct but related alkaline phosphatases: intestinal, placental, placental-like, and liver/bone/kidney (tissue non-specific) . The first three are located together on chromosome 2, while the tissue non-specific form is located on chromosome 1. The product of this gene is a membrane bound glycosylated enzyme that is not expressed in any particular tissue and is, therefore, referred to as the tissue-nonspecific form of the enzyme. The exact physiological function of the alkaline phosphatases is not known. A proposed function of this form of the enzyme is matrix mineralization; however, mice that lack a functional form of this enzyme show normal skeletal development. This enzyme has been linked directly to hypophosphatasia, a disorder that is characterized by hypercalcemia and includes skeletal defects. The character of this disorder can vary, however, depending on the specific mutation since this determines age of onset and severity of symptoms. Alternatively spliced transcript variants have been described.
Abbreviation
Alkaline Phosphatase
UniProt
P05186
Host
Rabbit
Reactivity
Human; Rat
Immunogen
A synthetic peptide of human Alkaline Phosphatase, Tissue Non-Specific
Target
AKP2; Alkaline phosphatase liver/bone/kidney; Alkaline phosphatase liver/bone/kidney isozyme; Alkaline phosphatase tissue nonspecific isozyme; Alkaline phosphatase; tissue-nonspecific isozyme; Alkaline phosphomonoesterase; Alpl; AP TNAP; AP-TNAP; APTNAP; BAP; FLJ40094; FLJ93059; Glycerophosphatase; HOPS; Liver/bone/kidney type alkaline phosphatase; MGC161443; MGC167935; PHOA; PPBT; Tissue non specific alkaline phosphatase; Tissue nonspecific ALP; TNAP; TNSALP
Clonality
Monoclonal
Clone
R08-6H0
Conjugation
Unconjugated
Applications
WB; IHC-P; IF
Field of Research
Cancer; Cell Biology; Tags and Cell Markers
Purification
Affinity Purified
Concentration
300 μg/mL
Dilution
WB 1:1000-1:2000; IHC 1:50-1:100; IF 1:50-1:100
Buffer
50mM Tris-Glycine (pH 7.4), 0.15M NaCl, 40% Glycerol, 0.01% Sodium azide and 0.05% protective protein
Shipping Conditions
The product is shipped with ice pack, upon receipt, store it immediately at the temperature recommended.
Storage Conditions
Store at -20°C Valid for 12 months. Avoid freeze / thaw cycles.
Product Datasheet
https://789.bio/ea/rzlx1r
Product MSDS
https://789.bio/eb/bP88S4
Calculated Molecular Weight
57kDa
Observed Molecular Weight
80kDa
Citation 01
https://onlinelibrary.wiley.com/doi/abs/10.1002/jor.23245
Isotype
IgG
Available Sizes
Curated Selection
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