Recombinant EGFR Monoclonal Antibody
Product Specifications
Background
EGFR, also named as ERBB1, is a cell-surface receptor for members of the epidermal growth factor family (EGF-family) of extracellular protein ligands. Binding of the protein to a ligand induces receptor dimerization and tyrosine autophosphorylation and leads to cell proliferation. The gene resides on chromosome 7p12, encoding a 170 kDa membrane-associated glycoprotein. Recent studies have shown EGFR plays a critical role in cancer development and progression, including cell proliferation, apoptosis, angiogenesis, and metastatic spread. Mutations in this gene are associated with lung cancer.
Abbreviation
EGFR
UniProt
P00533
Host
Rabbit
Reactivity
Human; Mouse
Immunogen
A synthetic peptide of human EGFR
Target
Cell growth inhibiting protein 40; Cell proliferation inducing protein 61; EGF R; EGFR; Epidermal growth factor receptor (avian erythroblastic leukemia viral (v erb b) oncogene homolog) ; Epidermal growth factor receptor; erb-b2 receptor tyrosine kinase 1; ERBB; ERBB1; Errp; HER1; mENA; NISBD2; SA7; wa2; Wa5
Clonality
Monoclonal
Clone
R03-6B1
Conjugation
Unconjugated
Applications
WB; IF
Field of Research
Cancer; Signal Transduction
Purification
Affinity Purified
Concentration
300 μg/mL
Dilution
WB 1:1000-1:2000; IF 1:50-1:200
Buffer
50mM Tris-Glycine (pH 7.4), 0.15M NaCl, 40% Glycerol, 0.01% Sodium azide and 0.05% protective protein
Shipping Conditions
The product is shipped with ice pack, upon receipt, store it immediately at the temperature recommended.
Storage Conditions
Store at -20°C Valid for 12 months. Avoid freeze / thaw cycles.
Calculated Molecular Weight
134kDa
Observed Molecular Weight
175kDa
Isotype
IgG
Available Sizes
Documents
Curated Selection
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