Recombinant Bax Monoclonal Antibody
Product Specifications
Background
BAX, also named as BCL2L4, is a pro-apoptotic member of the Bcl-2 protein family, which plays a pivotal role in controlling cell life and death. Bax largely localizes to the cytoplasm of healthy cells, but accumulates on the outer mitochondrial membrane upon apoptosis induction . BAX can commit a cell to apoptosis by translocation from the cytosol to the mitochondria and permeabilization of the outer mitochondrial membrane, which leads to the release of cytochrome c from mitochondria . The expression of BAX is upregulated by the tumor suppressor protein p53, and BAX has been shown to be involved in p53-mediated apoptosis .
Abbreviation
Bax
UniProt
Q07812
Host
Rabbit
Reactivity
Human; Mouse; Rat
Immunogen
A synthetic peptide of human Bax
Target
Apoptosis regulator BAX; BAX; Bax-protein; BAX; BAXA; Baxdelta2G9; Baxdelta2G9omega; Baxdelta2omega; Bcl-2-like protein 4; BCL2 associated X protein; BCL2 associated X protein omega; BCL2 associated X protein transcript variant delta2; Bcl2-L-4; BCL2L4; membrane isoform alpha
Clonality
Monoclonal
Clone
R03-1D3
Conjugation
Unconjugated
Applications
WB; IHC-P
Field of Research
Cancer; Cell Biology; Metabolism
Purification
Affinity Purified
Concentration
300 μg/mL
Dilution
WB 1:500-1:1000; IHC 1:20-1:100
Buffer
50mM Tris-Glycine (pH 7.4), 0.15M NaCl, 40% Glycerol, 0.01% Sodium azide and 0.05% protective protein
Shipping Conditions
The product is shipped with ice pack, upon receipt, store it immediately at the temperature recommended.
Storage Conditions
Store at -20°C Valid for 12 months. Avoid freeze / thaw cycles.
Product Datasheet
https://789.bio/ea/zskl10
Product MSDS
https://789.bio/eb/SCGKuL
Calculated Molecular Weight
21kDa
Observed Molecular Weight
20kDa
Isotype
IgG
Available Sizes
Curated Selection
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