Phospho-ERK 1/2 (Thr202/Tyr204) Polyclonal Antibody

Product Specifications

Background

The protein encoded by this gene is a member of the MAP kinase family. MAP kinases, also known as extracellular signal-regulated kinases (ERKs), act as an integration point for multiple biochemical signals, and are involved in a wide variety of cellular processes such as proliferation, differentiation, transcription regulation and development. The activation of this kinase requires its phosphorylation by upstream kinases. Upon activation, this kinase translocates to the nucleus of the stimulated cells, where it phosphorylates nuclear targets. Two alternatively spliced transcript variants encoding the same protein, but differing in the UTRs, have been reported for this gene.

Abbreviation

ERK1/2

UniProt

P63085, Q63844

Host

Rabbit

Reactivity

Mouse; Rat

Immunogen

KLH conjugated Synthetic peptide corresponding to Mouse ERK2

Target

MAPK3; ERK1; PRKM3; Mitogen-activated protein kinase 3; MAP kinase 3; MAPK 3; ERT2; Extracellular signal-regulated kinase 1; ERK-1; Insulin-stimulated MAP2 kinase; MAP kinase isoform p44; p44-MAPK; Microtubule-associated protein 2 kinase

Clonality

Polyclonal

Conjugation

Unconjugated

Applications

Field of Research

Cancer; Neuroscience; Signal Transduction; Stem Cells

Purification

Affinity purification

Concentration

1.1 mg/mL

Dilution

WB 1:500-1:2000

Buffer

PBS with 0.02% sodium azide, 1% protective protein and 50% glycerol, pH7.4

Shipping Conditions

The product is shipped with ice pack, upon receipt, store it immediately at the temperature recommended.

Storage Conditions

Store at -20°C Valid for 12 months. Avoid freeze / thaw cycles.

Calculated Molecular Weight

42/44kDa

Observed Molecular Weight

42/44kDa

Citation 01

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7695744/

Citation 02

https://link.springer.com/article/10.1007/s12079-022-00703-0

Citation 03

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5523073/

Citation 04

https://www.koreascience.or.kr/article/JAKO202025164428524.page

Citation 05

https://www.tandfonline.com/doi/abs/10.1080/08941939.2022.2164813

Isotype

IgG

Available Sizes

Documents

Product Datasheet

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