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Mineralocorticoid receptor Polyclonal Antibody

Product Specifications

Background

This gene encodes the mineralocorticoid receptor, which mediates aldosterone actions on salt and water balance within restricted target cells. The protein functions as a ligand-dependent transcription factor that binds to mineralocorticoid response elements in order to transactivate target genes. Mutations in this gene cause autosomal dominant pseudohypoaldosteronism type I, a disorder characterized by urinary salt wasting. Defects in this gene are also associated with early onset hypertension with severe exacerbation in pregnancy. Alternative splicing results in multiple transcript variants.

Abbreviation

Mineralocorticoid receptor

UniProt

P08235

Host

Rabbit

Reactivity

Human

Immunogen

KLH conjugated Synthetic peptide corresponding to Mouse Mineralocorticoid receptor

Target

Aldosterone receptor; MCR; MGC133092; Mineralocorticoid receptor; MLR; MR; NR3 C2; NR3C2; NR3C2 protein; Nuclear receptor subfamily 3 group C member 2

Clonality

Polyclonal

Conjugation

Unconjugated

Applications

WB

Field of Research

Signal Transduction; Cardiovascular; Epigenetics and Nuclear Signaling

Purification

Affinity purification

Concentration

1.3 mg/mL

Dilution

WB 1:500-1:2000

Buffer

PBS with 0.02% sodium azide, 1% protective protein and 50% glycerol, pH7.4

Shipping Conditions

The product is shipped with ice pack, upon receipt, store it immediately at the temperature recommended.

Storage Conditions

Store at -20°C Valid for 12 months. Avoid freeze / thaw cycles.

Product Datasheet

https://789.bio/ea/pr00go

Product MSDS

https://789.bio/eb/98qrj5

Calculated Molecular Weight

107kDa

Observed Molecular Weight

107kDa

Isotype

IgG

Available Sizes

Curated Selection

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