PPARA Polyclonal Antibody
Product Specifications
Background
Peroxisome proliferator-activated receptor alpha (PPARA) is a ligand-activated transcription factor that belongs to the PPAR nuclear receptor superfamily. PPARA is essential in the modulation of lipid transport and metabolism, mainly through activating mitochondrial and peroxisomal fatty acid β-oxidation pathways. In addition, PPARA seems to decrease inflammation mainly through direct interaction with NF-κB, causing inhibition of its signaling pathway or reducing the activated levels of NF-κB and subsequent inflammation. Furthermore, PPARA was implicated in the attenuation of oxidative stress in alcoholic liver disease when treated with polyenephosphatidylcholine through downregulation of ROS-generating enzymes such as ethanol-inducible cytochrome P450 2E1 (CYP2E1), acyl-CoA oxidase, and NADPH oxidase.
Abbreviation
PPARA
UniProt
P23204, P37230
Host
Rabbit
Reactivity
Mouse; Rat
Immunogen
KLH conjugated Synthetic peptide corresponding to Mouse PPARα
Target
HPPAR; MGC2237; MGC2452; NR1C1; Nuclear receptor subfamily 1 group C member 1; OTTHUMP00000197740; OTTHUMP00000197741; Peroxisome proliferative activated receptor alpha; Peroxisome proliferator activated receptor alpha; Peroxisome proliferator-activated receptor alpha; PPAR; PPAR-alpha; ppara; PPARA; PPARalpha
Clonality
Polyclonal
Conjugation
Unconjugated
Applications
IHC
Field of Research
Cancer; Cardiovascular; Epigenetics and Nuclear Signaling; Metabolism; Signal Transduction
Purification
Affinity purification
Concentration
0.6 mg/mL
Dilution
IHC 1:200-1:500
Buffer
PBS with 0.02% sodium azide, 1% protective protein and 50% glycerol, pH7.4
Shipping Conditions
The product is shipped with ice pack, upon receipt, store it immediately at the temperature recommended.
Storage Conditions
Store at -20°C Valid for 12 months. Avoid freeze / thaw cycles.
Product Datasheet
https://789.bio/ea/krxmsc
Product MSDS
https://789.bio/eb/jHGCuD
Isotype
IgG
Available Sizes
Curated Selection
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