E-Cadherin Monoclonal Antibody
Product Specifications
Background
This gene is a classical cadherin from the cadherin superfamily. The encoded protein is a calcium dependent cell-cell adhesion glycoprotein comprised of five extracellular cadherin repeats, a transmembrane region and a highly conserved cytoplasmic tail. Mutations in this gene are correlated with gastric, breast, colorectal, thyroid and ovarian cancer. Loss of function is thought to contribute to progression in cancer by increasing proliferation, invasion, and/or metastasis. The ectodomain of this protein mediates bacterial adhesion to mammalian cells and the cytoplasmic domain is required for internalization. Identified transcript variants arise from mutation at consensus splice sites.
Abbreviation
E-Cadherin
UniProt
P09803, Q9R0T4
Host
Mouse
Reactivity
Mouse; Rat
Immunogen
Recombinant protein corresponding to MouseE-cadherin
Target
Arc 1; CADH1; Cadherin 1; cadherin 1 type 1 E-cadherin; Cadherin1; CAM 120/80; CD 324; CD324; CD324 antigen; cdh1; CDHE; E-Cad/CTF3; E-cadherin; ECAD; Epithelial cadherin; epithelial calcium dependant adhesion protein; LCAM; Liver cell adhesion molecule; UVO; Uvomorulin
Clonality
Monoclonal
Clone
EC125D
Conjugation
Unconjugated
Applications
IHC
Field of Research
Cancer; Developmental Biology; Signal Transduction
Purification
Affinity purification
Concentration
1.6 mg/mL
Dilution
IHC 1:200-1:800
Buffer
PBS with 0.02% sodium azide, 1% protective protein and 50% glycerol, pH7.4
Shipping Conditions
The product is shipped with ice pack, upon receipt, store it immediately at the temperature recommended.
Storage Conditions
Store at -20°C Valid for 12 months. Avoid freeze / thaw cycles.
Product Datasheet
https://789.bio/ea/puqlhl
Product MSDS
https://789.bio/eb/aTmnr5
Citation 01
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8631930/
Isotype
IgG
Available Sizes
Curated Selection
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