HDHODH-IN-16
HDHODH-IN-16 (Compound 3t) is a human dihydroorotate dehydrogenase (hDHODH) inhibitor, with an IC50 of 0.11 μM. hDHODH-IN-16 shows very low cytotoxicity to healthy HaCaT cells, with an IC50 value greater than 200 µM[1].
Product Specifications
UNSPSC
12352005
Target
Dihydroorotate Dehydrogenase
Type
Reference compound
Related Pathways
Metabolic Enzyme/Protease
Field of Research
Others
Assay Protocol
https://www.medchemexpress.com/hdhodh-in-16.html
Smiles
O=C(N(CCCCCC)C1=O)C2=C1C3=CC=CC=C3N=C2C
Molecular Formula
C18H20N2O2
Molecular Weight
296.36
References & Citations
[1]Marina G Dimitrijević, et al. Discovery of a new class of potent pyrrolo[3,4-c]quinoline-1,3-diones based inhibitors of human dihydroorotate dehydrogenase: Synthesis, pharmacological and toxicological evaluation. Bioorg Chem. 2024 Jun:147:107359.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
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