HDHODH-IN-16

HDHODH-IN-16 (Compound 3t) is a human dihydroorotate dehydrogenase (hDHODH) inhibitor, with an IC50 of 0.11 μM. hDHODH-IN-16 shows very low cytotoxicity to healthy HaCaT cells, with an IC50 value greater than 200 µM[1].

Product Specifications

UNSPSC

12352005

Target

Dihydroorotate Dehydrogenase

Type

Reference compound

Related Pathways

Metabolic Enzyme/Protease

Field of Research

Others

Assay Protocol

https://www.medchemexpress.com/hdhodh-in-16.html

Smiles

O=C(N(CCCCCC)C1=O)C2=C1C3=CC=CC=C3N=C2C

Molecular Formula

C18H20N2O2

Molecular Weight

296.36

References & Citations

[1]Marina G Dimitrijević, et al. Discovery of a new class of potent pyrrolo[3,4-c]quinoline-1,3-diones based inhibitors of human dihydroorotate dehydrogenase: Synthesis, pharmacological and toxicological evaluation. Bioorg Chem. 2024 Jun:147:107359.