CYCS Polyclonal Antibody
Product Specifications
Background
Cytochrome c is a 12-15 kDa electron transporting protein located in the inner mitochondrial membrane. Upon apoptotic stimulation, cytochrome c can be released from mitochondria into cytoplasm, resulting in caspase-3 activation and apoptosis. Measurement of cytochrome c release from the mitochondria is useful for detection of the onset of apoptosis in cells. In addition, cytochrome c can also leave cells and be detectable in extra-cellular medium of apoptotic cells and serum of cancer patients. The level of serum cytochrome c may serve as a prognostic maker during cancer therapy.
Abbreviation
CYCS
UniProt
P99999, P62898, P62897
Host
Rabbit
Reactivity
Human; Mouse; Rat
Immunogen
KLH conjugated Synthetic peptide corresponding to Mouse Cytochrome c
Target
Cytochrome C; Somatic; CYC; Cytochrome C; THC4; HCS.
Clonality
Polyclonal
Conjugation
Unconjugated
Applications
WB; IHC; IF
Field of Research
Cancer; Cell Biology; Cardiovascular; Metabolism; Signal Transduction
Purification
Affinity purification
Concentration
1.5 mg/mL
Dilution
WB 1:500-1:2000; IHC 1:500-1:1000; IF 1:200-1:800
Buffer
PBS with 0.02% sodium azide, 1% protective protein and 50% glycerol, pH7.4
Shipping Conditions
The product is shipped with ice pack, upon receipt, store it immediately at the temperature recommended.
Storage Conditions
Store at -20°C Valid for 12 months. Avoid freeze / thaw cycles.
Calculated Molecular Weight
12kDa
Observed Molecular Weight
12kDa
Citation 01
https://link.springer.com/article/10.1007/s11696-019-00894-8
Isotype
IgG
Available Sizes
Curated Selection
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