(KO Validated) IGF1R Polyclonal Antibody
Product Specifications
Background
This receptor binds insulin-like growth factor with a high affinity. It has tyrosine kinase activity. The insulin-like growth factor I receptor plays a critical role in transformation events. Cleavage of the precursor generates alpha and beta subunits. It is highly overexpressed in most malignant tissues where it functions as an anti-apoptotic agent by enhancing cell survival. Alternatively spliced transcript variants encoding distinct isoforms have been found for this gene.
Abbreviation
IGF1R
UniProt
P08069
Host
Rabbit
Reactivity
Human; Mouse; Rat
Immunogen
A synthetic peptide of human IGF1R
Target
IGF1R; CD221; IGFIR; IGFR; JTK13
Clonality
Polyclonal
Conjugation
Unconjugated
Applications
WB
Field of Research
Cancer; Developmental Biology; Signal Transduction
Purification
Affinity purification
Concentration
1 mg/mL
Dilution
WB 1:500-1:2000
Buffer
PBS with 0.01% thiomersal,50% glycerol, pH7.3.
Shipping Conditions
The product is shipped with ice pack, upon receipt, store it immediately at the temperature recommended.
Storage Conditions
Store at -20°C Valid for 12 months. Avoid freeze / thaw cycles.
Calculated Molecular Weight
154kDa
Observed Molecular Weight
100KDa
Isotype
IgG
Available Sizes
Curated Selection
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