5'-Phosphoguanylyl- (3',5') -guanosine

5'-Phosphoguanylyl- (3',5') -guanosine (pGpG) is an intermediate molecule produced by the pathway for enzymatic cyclic diguanylate (c-di-GMP) degradation. 5'-Phosphoguanylyl- (3',5') -guanosine can be used to detect the metabolism of nucleic acids[1][2].

Product Specifications

CAS Number

[33008-99-0]

Product Name Alternative

PGpG

UNSPSC

12352005

Target

STING

Type

Reference compound

Related Pathways

Immunology/Inflammation

Applications

Metabolism-protein/nucleotide metabolism

Field of Research

Metabolic Disease

Assay Protocol

https://www.medchemexpress.com/5-phosphoguanylyl-3-5-guanosine.html

Purity

95.77

Solubility

H2O : 50 mg/mL (ultrasonic)

Smiles

O=C1C2=C(N([C@H]3[C@H](O)[C@H](O)[C@@H](COP(O)(O[C@H]4[C@@H](O)[C@H](N(C=N5)C6=C5C(N=C(N)N6)=O)O[C@@H]4COP(O)(O)=O)=O)O3)C=N2)NC(N)=N1

Molecular Formula

C20H26N10O15P2

Molecular Weight

708.43

References & Citations

[1]Nesbitt NM, et, al. Modification of a bi-functional diguanylate cyclase-phosphodiesterase to efficiently produce cyclic diguanylate monophosphate. Biotechnol Rep (Amst) . 2015 May 5;7:30-37.|[2]Cohen D, et, al. Oligoribonuclease is a central feature of cyclic diguanylate signaling in Pseudomonas aeruginosa. Proc Natl Acad Sci U S A. 2015 Sep 8;112 (36) :11359-64.