DS18561882

DS18561882 is a highly potent, isozyme-selective methylenetetrahydrofolate dehydrogenase 2 (MTHFD2) inhibitor with an IC50 value of 0.0063 μM. DS18561882 also has inhibitory effect on MTHFD1 (IC50=0.57 μM) . DS18561882 exhibits a good oral pharmacokinetic profile[1].

Product Specifications

CAS Number

[2227149-22-4]

UNSPSC

12352005

Target

Methylenetetrahydrofolate Dehydrogenase (MTHFD)

Type

Reference compound

Related Pathways

Metabolic Enzyme/Protease

Applications

Cancer-programmed cell death

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/ds18561882.html

Purity

99.87

Solubility

DMSO : 100 mg/mL (ultrasonic)

Smiles

CS(=O)(NC1=CC=C(C(N2CCC(C3=CC=C(N4C[C@H](C)N(C)CC4)C(C)=C3O5)=C(C5=O)C2)=O)C=C1OC(F)(F)F)=O

Molecular Formula

C28H31F3N4O6S

Molecular Weight

608.63

References & Citations

[1]Kawai J, et al. Discovery of a Potent, Selective, and Orally Available MTHFD2 Inhibitor (DS18561882) with In Vivo Anti-Tumor Activity. J Med Chem. 2019 Oct 22.