PGC1 alpha Polyclonal Antibody

Product Specifications

Background

The protein encoded by this gene is a transcriptional coactivator that regulates the genes involved in energy metabolism. This protein interacts with PPARgamma, which permits the interaction of this protein with multiple transcription factors. This protein can interact with, and regulate the activities of, cAMP response element binding protein (CREB) and nuclear respiratory factors (NRFs) . It provides a direct link between external physiological stimuli and the regulation of mitochondrial biogenesis, and is a major factor that regulates muscle fiber type determination. This protein may be also involved in controlling blood pressure, regulating cellular cholesterol homoeostasis, and the development of obesity.

Abbreviation

PGC1 alpha

UniProt

Q9UBK2

Host

Rabbit

Reactivity

Human; Mouse; Rat

Immunogen

A synthetic peptide of human PGC1 alpha (NP_037393.1) .

Target

PPARGC1A; LEM6; PGC-1 (alpha) ; PGC-1alpha; PGC-1v; PGC1; PGC1A; PPARGC1; PPARG coactivator 1 alpha; PGC1 alpha

Clonality

Polyclonal

Conjugation

Unconjugated

Applications

WB; IF

Field of Research

Cancer; Cardiovascular; Epigenetics and Nuclear Signaling; Metabolism

Purification

Affinity purification

Concentration

1mg/mL

Dilution

WB 1:500-1:2000; IF 1:50-1:200

Buffer

PBS with 0.02% sodium azide, 50% glycerol, pH7.3.

Shipping Conditions

The product is shipped with ice pack, upon receipt, store it immediately at the temperature recommended.

Storage Conditions

Store at -20°C Valid for 12 months. Avoid freeze / thaw cycles.

Calculated Molecular Weight

14kDa/30kDa/31kDa/33kDa/77kDa/89kDa/91kDa

Observed Molecular Weight

110kDa

Citation 01

https://www.sciencedirect.com/science/article/pii/S0024320522009584

Citation 02

https://onlinelibrary.wiley.com/doi/abs/10.1096/fj.201901510RR

Citation 03

https://www.sciencedirect.com/science/article/pii/S0024320522003496

Isotype

IgG

Available Sizes

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