HDAC3 Polyclonal Antibody
Product Specifications
Background
Histones play a critical role in transcriptional regulation, cell cycle progression, and developmental events. Histone acetylation/deacetylation alters chromosome structure and affects transcription factor access to DNA. The protein encoded by this gene belongs to the histone deacetylase/acuc/apha family. It has histone deacetylase activity and represses transcription when tethered to a promoter. It may participate in the regulation of transcription through its binding with the zinc-finger transcription factor YY1. This protein can also down-regulate p53 function and thus modulate cell growth and apoptosis. This gene is regarded as a potential tumor suppressor gene.
Abbreviation
HDAC3
UniProt
O15379
Host
Rabbit
Reactivity
Human; Mouse; Rat
Immunogen
A synthetic peptide of human HDAC3 (NP_003874.2) .
Target
HD3; RPD3; RPD3-2; HDAC3
Clonality
Polyclonal
Conjugation
Unconjugated
Applications
WB; IHC; IF
Field of Research
Cancer; Cardiovascular; Epigenetics and Nuclear Signaling; Metabolism; Stem Cells
Purification
Affinity purification
Concentration
1mg/mL
Dilution
WB 1:500-1:2000; IHC 1:50-1:200; IF 1:50-1:200
Buffer
PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Shipping Conditions
The product is shipped with ice pack, upon receipt, store it immediately at the temperature recommended.
Storage Conditions
Store at -20°C Valid for 12 months. Avoid freeze / thaw cycles.
Calculated Molecular Weight
48kDa/49kDa
Observed Molecular Weight
48kDa
Isotype
IgG
Available Sizes
Curated Selection
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