Tizolemide
Tizolemide is a sulphonamide diuretic compound that has alkaline properties and is cleared by a tubular transport system. Tizolemide induces changes of passive transport components across the basolateral membrane of isolated frog skin[1][2].
Product Specifications
CAS Number
56488-58-5
UNSPSC
12352005
Target
Sodium Channel
Type
Reference compound
Related Pathways
Membrane Transporter/Ion Channel
Field of Research
Cardiovascular Disease
Assay Protocol
https://www.medchemexpress.com/tizolemide.html
Smiles
O=S(N)(C1=CC(C2(N(C)/C(SC2)=N/C)O)=CC=C1Cl)=O
Molecular Formula
C11H14ClN3O3S2
Molecular Weight
335.83
References & Citations
[1]Beermann B, et al. Diuretic effect and pharmacokinetics of tizolemide in subjects with normal and decreased renal function. Clin Nephrol. 1983 Mar;19 (3) :124-31. |[2]Nagel W, et al. Tizolemide-induced changes of passive transport components across the basolateral membrane of isolated frog skin. Pflugers Arch. 1981 Sep;391 (3) :219-25.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Frequently Asked Questions
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