BWA-522 intermediate-1
BWA-522 intermediate-1 is an intermediate in the synthesis of PROTAC BWA-522 and serves as a ligand molecule for cereblon E3 ubiquitin ligase. BWA-522 is an orally active small molecule protein-targeting chimera (PROTAC) that has significant degradation effects on AR-FL and AR-V7[1].
Product Specifications
CAS Number
2241315-66-0
UNSPSC
12352005
Hazard Statement
H302, H315, H319, H335
Target
Ligands for E3 Ligase
Type
Reference compound
Related Pathways
PROTAC
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/bwa-522-intermediate-1.html
Purity
99.27
Solubility
10 mM in DMSO
Smiles
O=CC1CCN(C2=CC3=C(C(N(C(CC4)C(NC4=O)=O)C3=O)=O)C=C2)CC1
Molecular Formula
C19H19N3O5
Molecular Weight
369.37
Precautions
H302, H315, H319, H335
References & Citations
[1]Arvinas Operations, et al. Indazole based compounds and associated methods of use. World Intellectual Property Organization, WO2021194879 A1 2021-09-30.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
Cereblon
Available Sizes
Frequently Asked Questions
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