Clobutinol (hydrochloride)

Clobutinol hydrochloride is a compound that has anti-tussive effects. Clobutinol hydrochloride affects heart rate and blood pressure, it can be used for cough related research[1][2][3].

Product Specifications

CAS Number

[1215-83-4]

UNSPSC

12352005

Hazard Statement

H302-H315-H319-H335

Target

Potassium Channel

Type

Reference compound

Related Pathways

Membrane Transporter/Ion Channel

Applications

COVID-19-immunoregulation

Field of Research

Inflammation/Immunology; Cardiovascular Disease

Assay Protocol

https://www.medchemexpress.com/clobutinol-hydrochloride.html

Concentration

10mM

Purity

99.22

Solubility

DMSO : 100 mg/mL (ultrasonic)

Smiles

ClC1=CC=C(CC(C)(C(CN(C)C)C)O)C=C1.Cl

Molecular Formula

C14H23Cl2NO

Molecular Weight

292.25

Precautions

P261-P264-P270-P271-P280-P302+P352-P304+P340-P330-P362+P364-P405-P501

References & Citations

[1]Deisemann H, et al. Effects of common antitussive drugs on the hERG potassium channel current. J Cardiovasc Pharmacol. 2008 Dec;52 (6) :494-9.|[2]Salonen RO. Comparison of the effects of two opioid antitussives, vadocaine hydrochloride, clobutinol and lidocaine on lung mechanics in guinea-pigs. Arzneimittelforschung. 1988 Apr;38 (4A) :609-12.|[3]Takahara A, et al. Clobutinol delays ventricular repolarization in the guinea pig heart: comparison with cardiac effects of HERG K+ channel inhibitor E-4031. J Cardiovasc Pharmacol. 2009 Dec;54 (6) :552-9.