Clobutinol (hydrochloride)
Clobutinol hydrochloride is a compound that has anti-tussive effects. Clobutinol hydrochloride affects heart rate and blood pressure, it can be used for cough related research[1][2][3].
Product Specifications
CAS Number
1215-83-4
UNSPSC
12352005
Hazard Statement
H302-H315-H319-H335
Target
Potassium Channel
Type
Reference compound
Related Pathways
Membrane Transporter/Ion Channel
Applications
COVID-19-immunoregulation
Field of Research
Inflammation/Immunology; Cardiovascular Disease
Assay Protocol
https://www.medchemexpress.com/clobutinol-hydrochloride.html
Concentration
10mM
Purity
99.22
Solubility
DMSO : 100 mg/mL (ultrasonic)
Smiles
ClC1=CC=C(CC(C)(C(CN(C)C)C)O)C=C1.Cl
Molecular Formula
C14H23Cl2NO
Molecular Weight
292.25
Precautions
P261-P264-P270-P271-P280-P302+P352-P304+P340-P330-P362+P364-P405-P501
References & Citations
[1]Deisemann H, et al. Effects of common antitussive drugs on the hERG potassium channel current. J Cardiovasc Pharmacol. 2008 Dec;52 (6) :494-9.|[2]Salonen RO. Comparison of the effects of two opioid antitussives, vadocaine hydrochloride, clobutinol and lidocaine on lung mechanics in guinea-pigs. Arzneimittelforschung. 1988 Apr;38 (4A) :609-12.|[3]Takahara A, et al. Clobutinol delays ventricular repolarization in the guinea pig heart: comparison with cardiac effects of HERG K+ channel inhibitor E-4031. J Cardiovasc Pharmacol. 2009 Dec;54 (6) :552-9.
Shipping Conditions
Room Temperature
Storage Conditions
4°C (Powder, sealed storage, away from moisture)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Available Sizes
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