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ASC / TMS1 Polyclonal Antibody

Product Specifications

Background

This gene encodes an adaptor protein that is composed of two protein-protein interaction domains: a N-terminal PYRIN-PAAD-DAPIN domain (PYD) and a C-terminal caspase-recruitment domain (CARD) . The PYD and CARD domains are members of the six-helix bundle death domain-fold superfamily that mediates assembly of large signaling complexes in the inflammatory and apoptotic signaling pathways via the activation of caspase. In normal cells, this protein is localized to the cytoplasm; however, in cells undergoing apoptosis, it forms ball-like aggregates near the nuclear periphery. Two transcript variants encoding different isoforms have been found for this gene.

Abbreviation

ASC / TMS1

UniProt

Q9ULZ3

Host

Rabbit

Reactivity

Human; Mouse; Rat

Immunogen

Recombinant fusion protein of human ASC / TMS1 (NP_037390.2) .

Target

PYCARD; ASC; CARD5; TMS; TMS-1; TMS1; PYD and CARD domain containing; ASC / TMS1

Clonality

Polyclonal

Conjugation

Unconjugated

Applications

WB; IF

Field of Research

Cancer; Cell Biology

Purification

Affinity purification

Concentration

1mg/mL

Dilution

WB 1:500-1:2000; IF 1:50-1:200

Buffer

PBS with 0.02% sodium azide, 50% glycerol, pH7.3.

Shipping Conditions

The product is shipped with ice pack, upon receipt, store it immediately at the temperature recommended.

Storage Conditions

Store at -20°C Valid for 12 months. Avoid freeze / thaw cycles.

Product Datasheet

https://789.bio/ea/sr04ld

Product MSDS

https://789.bio/eb/uL8ev5

Calculated Molecular Weight

15kDa/19kDa/21kDa

Observed Molecular Weight

22kDa

Citation 01

https://www.sciencedirect.com/science/article/pii/S1567576923002242

Citation 02

https://www.nature.com/articles/s41598-022-04785-z

Citation 03

https://journals.lww.com/neuroreport/Fulltext/2021/06020/Protective_effects_of_melatonin_on_the_white.1.aspx?context=LatestArticles

Isotype

IgG

Available Sizes

Curated Selection

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