NEFL Polyclonal Antibody
Product Specifications
Background
Neurofilaments are type IV intermediate filament heteropolymers composed of light, medium, and heavy chains. Neurofilaments comprise the axoskeleton and they functionally maintain the neuronal caliber. They may also play a role in intracellular transport to axons and dendrites. This gene encodes the light chain neurofilament protein. Mutations in this gene cause Charcot-Marie-Tooth disease types 1F (CMT1F) and 2E (CMT2E), disorders of the peripheral nervous system that are characterized by distinct neuropathies. A pseudogene has been identified on chromosome Y.
Abbreviation
NEFL
UniProt
P07196
Host
Rabbit
Reactivity
Human; Mouse; Rat
Immunogen
Recombinant fusion protein of human NEFL (NP_006149.2) .
Target
NEFL; CMT1F; CMT2E; NF-L; NF68; NFL; PPP1R110
Clonality
Polyclonal
Conjugation
Unconjugated
Applications
IHC; IF
Field of Research
Cancer; Developmental Biology; Neuroscience; Signal Transduction; Stem Cells
Purification
Affinity purification
Concentration
1mg/mL
Dilution
IHC 1:50-1:200; IF 1:50-1:200
Buffer
PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Shipping Conditions
The product is shipped with ice pack, upon receipt, store it immediately at the temperature recommended.
Storage Conditions
Store at -20°C Valid for 12 months. Avoid freeze / thaw cycles.
Citation 01
https://onlinelibrary.wiley.com/doi/abs/10.1111/cpr.13345
Citation 02
https://www.mdpi.com/2073-4409/10/4/761
Isotype
IgG
Available Sizes
Curated Selection
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