PLA2G16 Polyclonal Antibody

Secretory phopholipase A2 (PLA2) enzymes cleave an acyl ester bond in the sn-2 position of glycerophospholipids. These extracellular proteins have a high disulfide bond content, low molecular mass (14 kDa), and require mM levels of Ca2+ for catalysis. They play a crucial role in the generation of arachidonates and eicosanoids, and have a number of biological actions including immunological responses, inflammation, cellular proliferation, vasoconstriction, and bronchioconstriction. Exhibits PLA1/2 activity, catalyzing the calcium-independent hydrolysis of acyl groups in various phosphatidylcholines (PC) and phosphatidylethanolamine (PE) . For most substrates, PLA1 activity is much higher than PLA2 activity. Specifically catalyzes the release of fatty acids from phospholipids in adipose tissue (By similarity) . N- and O-acylation activity is hardly detectable. Might decrease protein phosphatase 2A (PP2A) activity.

Adipose specific phospholipase A2; Adipose specific PLA2; Adipose-specific phospholipase A2; AdPLA; Ca independent phospholipase A1/2; Group XVI phospholipase A1/A2; Group XVI phospholipase A2; H rev 107 protein homolog; H REV107 1; H-rev 107 protein homolog; HRAS like suppressor 1; HRAS like suppressor 3; HRAS-like suppressor 1; HRAS-like suppressor 3; HREV107 1; HREV107 3; HREV107; HREV107-1; HREV107-3; HRSL3; HRSL3; Phospholipase A2 group XVI; Pla2g16; Renal carcinoma antigen NY REN 65 ; Renal carcinoma antigen NY-REN-65