BECN1 Polyclonal Antibody
Product Specifications
Background
Beclin-1 (BECN1), also known as ATG6 or VPS30, has a central role in autophagy, a process of programmed cell survival, which is increased during periods of cell stress and extinguished during the cell cycle. Beclin-1, may play a role in antiviral host defense. It protects against infection by a neurovirulent strain of Sindbis virus. Beclin-1 participates in the regulation of autophagy and has an important role in development, tumorigenesis, and neurodegeneration. A progressively reduced Beclin-1 expression is reported to correlate with the primary tumor growth of squamous cell carcinoma and adenocarcinoma of the lung. Caspase-mediated cleavage of Beclin 1 promotes crosstalk between apoptosis and autophagy.
Abbreviation
BECN1
UniProt
Q14457
Host
Rabbit
Reactivity
Human; Mouse; Rat
Immunogen
Synthetic peptide of human BECN1
Target
APG6; ATG 6; ATG6; ATG6 autophagy related 6 homolog; Bcl-2-interacting protein beclin; Beclin 1 (coiled coil moesin like BCL2 interacting protein) ; Beclin 1 autophagy related; Beclin-1; Beclin1; BECN 1; Becn1; BECN1; Coiled coil myosin like BCL2 interacting protein; Coiled-coil myosin-like BCL2-interacting protein; GT197; Protein GT197; VPS 30; VPS30
Clonality
Polyclonal
Conjugation
Unconjugated
Applications
WB; IHC
Field of Research
Cancer; Epigenetics and Nuclear Signaling; Metabolism; Microbiology; Signal Transduction
Purification
Antigen affinity purification
Concentration
0.84 mg/mL
Dilution
WB 1:500-1:2000; IHC 1:50-1:100
Buffer
PBS with 0.05% NaN3 and 40% Glycerol, pH7.4
Shipping Conditions
The product is shipped with ice pack, upon receipt, store it immediately at the temperature recommended.
Storage Conditions
Store at -20°C Valid for 12 months. Avoid freeze / thaw cycles.
Product Datasheet
https://789.bio/ea/g8rlu5
Product MSDS
https://789.bio/eb/j5SyD4
Calculated Molecular Weight
52 kDa
Observed Molecular Weight
Refer to figures
Citation 01
https://www.sciencedirect.com/science/article/pii/S0020138322006258
Citation 02
https://www.tandfonline.com/doi/abs/10.1080/01616412.2022.2159109
Isotype
IgG
Available Sizes
Curated Selection
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