HLA-DQB2 Polyclonal Antibody

HLA-DQB2 belongs to the family of HLA class II beta chain paralogs. Class II molecules are heterodimers consisting of an alpha (DQA) and a beta chain (DQB), both anchored in the membrane. They play a central role in the immune system by presenting peptides derived from extracellular proteins. Class II molecules are expressed in antigen presenting cells (APC: B lymphocytes, dendritic cells, macrophages) . Polymorphisms in the alpha and beta chains specify the peptide binding specificity, and typing for these polymorphisms is routinely done for bone marrow transplantation. However this gene, HLA-DQB2, is not routinely typed, as it is not thought to have an effect on transplantation. There is conflicting evidence in the literature and public sequence databases for the protein-coding capacity of HLA-DQB2. Because there is evidence of transcription and an intact ORF, HLA-DQB2 is represented in Entrez Gene and in RefSeq as a protein-coding locus.

DV19.1 (major histocompatibility complex; class II; DQ beta 2 (HLA-DXB) ) ; DX-beta; HLA class II histocompatibility antigen; DQ beta 2 chain; HLA class II histocompatibility antigen; DX beta chain; HLA DQB1; HLA DXB; major histocompatibility complex; class II; DQ beta 1; Major histocompatibility complex; class II; DQ beta 2; Major histocompatibility complex; class II; DX beta; MHC class II antigen DQB2