RIC8A Polyclonal Antibody
Product Specifications
Background
Guanine nucleotide exchange factor (GEF), which can activate some, but not all, G-alpha proteins. Able to activate GNAI1, GNAO1 and GNAQ, but not GNAS by exchanging bound GDP for free GTP. Involved in regulation of microtubule pulling forces during mitotic movement of chromosomes by stimulating G (i) -alpha protein, possibly leading to release G (i) -alpha-GTP and NuMA proteins from the NuMA-GPSM2-G (i) -alpha-GDP complex (By similarity) . Also acts as an activator for G (q) -alpha (GNAQ) protein by enhancing the G (q) -coupled receptor-mediated ERK activation.
Abbreviation
RIC8A
UniProt
Q9NPQ8
Host
Rabbit
Reactivity
Human; Mouse; Rat
Immunogen
Fusion protein of human RIC8A
Target
MGC104517; MGC131931; MGC148073; MGC148074; Protein Ric-8A; resistance to inhibitors of cholinesterase 8 homolog A (C. elegans) ; RIC8; RIC8A; RIC8A; Synembryn-A
Clonality
Polyclonal
Conjugation
Unconjugated
Applications
IHC
Field of Research
Cancer; Signal transduction
Purification
Antigen affinity purification
Concentration
1.44 mg/mL
Dilution
IHC 1:50-1:300
Buffer
PBS with 0.05% NaN3 and 40% Glycerol, pH7.4
Shipping Conditions
The product is shipped with ice pack, upon receipt, store it immediately at the temperature recommended.
Storage Conditions
Store at -20°C Valid for 12 months. Avoid freeze / thaw cycles.
Isotype
IgG
Available Sizes
Curated Selection
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