ITM2B Polyclonal Antibody
Product Specifications
Background
Amyloid precursor proteins are processed by beta-secretase and gamma-secretase to produce beta-amyloid peptides which form the characteristic plaques of Alzheimer disease. This gene encodes a transmembrane protein which is processed at the C-terminus by furin or furin-like proteases to produce a small secreted peptide which inhibits the deposition of beta-amyloid. Mutations which result in extension of the C-terminal end of the encoded protein, thereby increasing the size of the secreted peptide, are associated with two neurogenerative diseases, familial British dementia and familial Danish dementia.
Abbreviation
ITM2B
UniProt
Q9Y287
Host
Rabbit
Reactivity
Human; Mouse; Rat
Immunogen
Fusion protein of human ITM2B
Target
ABRI; ABri/ADan amyloid peptide; BRI 2; BRI; BRI2; BRICD 2B; BRICD2B; BRICHOS domain containing 2B; E25B; E3 16; E3-16; FBD; imBRI2; Immature BRI2; Integral membrane protein 2B; ITM 2B; ITM2B; ITM2B; Protein E25B; RDGCA; Transmembrane protein BRI
Clonality
Polyclonal
Conjugation
Unconjugated
Applications
WB
Field of Research
Neuroscience
Purification
Antigen affinity purification
Concentration
0.96 mg/mL
Dilution
WB 1:500-1:2000
Buffer
PBS with 0.05% NaN3 and 40% Glycerol, pH7.4
Shipping Conditions
The product is shipped with ice pack, upon receipt, store it immediately at the temperature recommended.
Storage Conditions
Store at -20°C Valid for 12 months. Avoid freeze / thaw cycles.
Product Datasheet
https://789.bio/ea/cl5vwl
Product MSDS
https://789.bio/eb/KezT08
Calculated Molecular Weight
30 kDa
Observed Molecular Weight
Refer to figures
Isotype
IgG
Available Sizes
Curated Selection
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