UNC13B Polyclonal Antibody
Product Specifications
Background
This gene is expressed in the kidney cortical epithelial cells and is upregulated by hyperglycemia. The encoded protein shares a high level of similarity to the rat homolog, and contains 3 C2 domains and a diacylglycerol-binding C1 domain. Hyperglycemia increases the levels of diacylglycerol, which has been shown to induce apoptosis in cells transfected with this gene and thus contribute to the renal cell complications of hyperglycemia. Studies in other species also indicate a role for this protein in the priming step of synaptic vesicle exocytosis.
Abbreviation
UNC13B
UniProt
O14795
Host
Rabbit
Reactivity
Human; Mouse; Rat
Immunogen
Fusion protein of human UNC13B
Target
Hmunc13; MGC133279; MGC133280; munc13; Munc13-2; Protein unc-13 homolog B; UN13B; unc-13 homolog B (C. elegans) ; UNC13; Unc13b; Unc13h2
Clonality
Polyclonal
Conjugation
Unconjugated
Applications
IHC
Field of Research
Neuroscience; Signal transduction
Purification
Antigen affinity purification
Concentration
1.5 mg/mL
Dilution
IHC 1:50-1:300
Buffer
PBS with 0.05% NaN3 and 40% Glycerol, pH7.4
Shipping Conditions
The product is shipped with ice pack, upon receipt, store it immediately at the temperature recommended.
Storage Conditions
Store at -20°C Valid for 12 months. Avoid freeze / thaw cycles.
Product Datasheet
https://789.bio/ea/wlrds8
Product MSDS
https://789.bio/eb/iL4KqH
Isotype
IgG
Available Sizes
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