PTPRN Polyclonal Antibody

IA-2/PTPRN is a member of the protein tyrosine phosphatase (PTP) family, which contains a transmembrane region, an intracellular PTP-like domain and an extracellular N-terminus. Experiments found that IA-2/PTPRN localizes to secretory granules and is exclusively expressed in neuroendocrine cells (including pancreatic islets cell) . IA-2/PTPRNwas found to be a major autoantigen in insulin-dependent diabetes mellitus and the detection of autoantibodies against IA-2/PTPRN is commonly used as a diabetes diagnosis marker.

CA 512; FLJ16131; IA 2; IA 2/PTP; IA2; IA2/PTP; ICA 3; ICA 512; ICA3; ICA512; Islet cell antigen 2; Islet cell antigen 512; Islet cell autoantigen 3; Protein tyrosine phosphatase like N; Protein tyrosine phosphatase like N precursor; Protein tyrosine phosphatase receptor type N; PTP IA 2; PTP IA-2; PTP IA2; PTPIA 2; PTPN; Ptprn; PTPRN protein; PTPRN; R PTP N; R-PTP-N; Receptor type tyrosine protein phosphatase like N; Receptor-type tyrosine-protein phosphatase-like N; RPTPN