GTPase Kras Polyclonal Antibody
Product Specifications
Background
KRAS, also called p21, is a member of the Ras superfamily of proteins. It is located on human chromosome 12, and contains four coding exons and a 5' non-coding exon (PMID: 12778136) . KRAS is a membrane-anchored guanosine triphosphate/guanosine diphosphate (GTP/GDP) -binding protein and is widely expressed in most human cells. Like other members of the Ras family, the KRAS protein is a GTPase, and it is involved in intracellular signal transduction and mainly responsible for EGFR-signaling activation (PMID: 19117687) . KRAS mutations have been found in various malignancies, including lung adenocarcinoma, mucinous adenoma, ductal carcinoma of the pancreas and colorectal carcinoma.
Abbreviation
KRAS
UniProt
P01116
Host
Rabbit
Reactivity
Human; Mouse; Rat
Immunogen
Recombinant Human KRAS protein expressed by E.coli.
Target
KRAS; KRAS2; RASK2; GTPase Kras; K-Ras 2; Ki-Ras; c-K-ras; c-Ki-ras; GTPase Kras
Clonality
Polyclonal
Conjugation
Unconjugated
Applications
WB
Field of Research
Cancer; Epigenetics and Nuclear Signaling; Signal Transduction
Purification
Antigen Affinity Purification
Concentration
1 mg/mL
Dilution
WB 1:1000-1:2000
Buffer
PBS with 0.02% sodium azide,1% protective protein and 50% glycerol, pH7.4
Shipping Conditions
The product is shipped with ice pack, upon receipt, store it immediately at the temperature recommended.
Storage Conditions
Store at -20°C Valid for 12 months. Avoid freeze / thaw cycles.
Calculated Molecular Weight
21 kDa
Observed Molecular Weight
21 kDa
Isotype
IgG
Available Sizes
Frequently Asked Questions
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