DnaseIPolyclonal Antibody
Product Specifications
Background
Deoxyribonuclease I (DNase I) is an endonuclease which is secreted to cleave DNA in the extracellular space down to an average of tetranucleotides with 5′ monophosphate and 3′ hydroxyl DNA ends . Both single-stranded DNA and double-stranded DNA are degraded by Dnase I. This nuclease appears to account for the major nucleolytic activity on DNA in serum and is responsible for the degradation of the majority of circulating DNA derived from apoptotic and necrotic cell death and from neutrophil extracellular traps. In addition to its role in the serum, it has been proposed as one of the deoxyribonucleases responsible for DNA fragmentation in the process of apoptosis.
Abbreviation
DnaseI
UniProt
P24855
Host
Rabbit
Reactivity
Human
Immunogen
Recombinant Human DnaseI protein expressed by E.coli.
Target
Deoxyribonuclease-1; DNASE1; DNL1; DRNI
Clonality
Polyclonal
Conjugation
Unconjugated
Applications
WB
Field of Research
Cancer; Cell Biology; Epigenetics and Nuclear Signaling; Metabolism
Purification
Antigen Affinity Purification
Concentration
1 mg/mL
Dilution
WB 1:1000-2000
Buffer
PBS with 0.02% sodium azide,1% protective protein and 50% glycerol, pH7.4
Shipping Conditions
The product is shipped with ice pack, upon receipt, store it immediately at the temperature recommended.
Storage Conditions
Store at -20°C Valid for 12 months. Avoid freeze / thaw cycles.
Calculated Molecular Weight
31kDa
Observed Molecular Weight
31kDa
Isotype
IgG
Available Sizes
Frequently Asked Questions
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