NPM1 Polyclonal Antibody
Product Specifications
Background
Nucleophosmin (NPM1, B23) is a putative ribosome assembly factor with a high affinity for peptides containing nuclear localization signals (NLSs) . The transport of proteins across the nuclear envelope is a selective, multistep process involving several cytoplasmic factors. Proteins must be recognized as import substrates, dock at the nuclear pore complex and translocate across the nuclear envelope in an ATP-dependent fashion. Several cytosolic and nuclear proteins that are central to this process have been identified. The 38 kDa nuclear protein nucleophosmin is involved in ribosomal assembly and rRNA transport. It is an abundant protein that is highly phosphorylated by Cdc2 kinase during mitosis.
Abbreviation
NPM1
UniProt
Q61937
Host
Rabbit
Reactivity
Human; Mouse; Rat
Immunogen
Recombinant Mouse Nucleophosmin protein
Target
B23; MGC104254; NO38; NPM; NPM; NPM1; Nucleolar phosphoprotein B23; Nucleolar protein NO38; Nucleophosmin (nucleolar phosphoprotein B23 numatrin) ; Nucleophosmin; nucleophosmin nucleoplasmin family member 1; Nucleophosmin/nucleoplasmin family member 1; Numatrin
Clonality
Polyclonal
Conjugation
Unconjugated
Applications
WB; IHC
Field of Research
Cancer; Epigenetics and Nuclear Signaling
Purification
Antigen Affinity Purification
Concentration
1 mg/mL
Dilution
WB 1:10000-1:20000; IHC 1:200-1:500
Buffer
PBS with 0.02% sodium azide,1% protective protein and 50% glycerol, pH7.4
Shipping Conditions
The product is shipped with ice pack, upon receipt, store it immediately at the temperature recommended.
Storage Conditions
Store at -20°C Valid for 12 months. Avoid freeze / thaw cycles.
Calculated Molecular Weight
32 kDa
Observed Molecular Weight
37 kDa
Isotype
IgG
Available Sizes
Frequently Asked Questions
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