BRCA2 Polyclonal Antibody
Product Specifications
Background
Inherited mutations in BRCA1 and this gene, BRCA2, confer increased lifetime risk of developing breast or ovarian cancer. Both BRCA1 and BRCA2 are involved in maintenance of genome stability, specifically the homologous recombination pathway for double-strand DNA repair. The BRCA2 protein contains several copies of a 70 aa motif called the BRC motif, and these motifs mediate binding to the RAD51 recombinase which functions in DNA repair. BRCA2 is considered a tumor suppressor gene, as tumors with BRCA2 mutations generally exhibit loss of heterozygosity (LOH) of the wild-type allele.
Abbreviation
BRCA2
UniProt
P51587
Host
Rabbit
Reactivity
Human; Rat
Immunogen
Recombinant Human Breast cancer type 2 susceptibility protein
Target
BRCA 2; BRCC 2; Breast and ovarian cancer susceptibility gene early onset antibody; BROVCA2; FACD; FAD 1; FANCB; GLM3
Clonality
Polyclonal
Conjugation
Unconjugated
Applications
WB; IHC; IF
Field of Research
Cancer; Epigenetics and Nuclear Signaling
Purification
Antigen Affinity Purification
Concentration
1 mg/mL
Dilution
WB 1:1000-1:3000; IHC 1:100-1:200; IF 1:100-1:400
Buffer
PBS with 0.02% sodium azide,1% protective protein and 50% glycerol, pH7.4
Shipping Conditions
The product is shipped with ice pack, upon receipt, store it immediately at the temperature recommended.
Storage Conditions
Store at -20°C Valid for 12 months. Avoid freeze / thaw cycles.
Calculated Molecular Weight
384 kDa
Observed Molecular Weight
384 kDa
Isotype
IgG
Available Sizes
Documents
Curated Selection
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