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Lamin B1 Polyclonal Antibody

Product Specifications

Background

The nuclear lamina consists of a two-dimensional matrix of proteins located next to the inner nuclear membrane. The lamin family of proteins make up the matrix and are highly conserved in evolution. During mitosis, the lamina matrix is reversibly disassembled as the lamin proteins are phosphorylated. Lamin proteins are thought to be involved in nuclear stability, chromatin structure and gene expression. Vertebrate lamins consist of two types, A and B. This gene encodes one of the two B type proteins, B1. Alternative splicing results in transcript variants and a duplication of this gene is associated with autosomal dominant adult-onset leukodystrophy (ADLD) .

Abbreviation

Lamin B1

UniProt

P70615

Host

Rabbit

Reactivity

Human; Mouse; Rat

Immunogen

Recombinant Rat Lamin-B1 protein expressed by E.coli

Target

ADLD; lamin B1; Lamin-B1; LMN; LMN2; LMNB; Lmnb1; LMNB1; MGC111419; OTTHUMP00000159218

Clonality

Polyclonal

Conjugation

Unconjugated

Applications

WB; IHC; IF

Field of Research

Cancer; Cell Biology; Signal Transduction; Tags and Cell Markers

Purification

Antigen Affinity Purification

Concentration

1 mg/mL

Dilution

WB 1:250-1:500; IHC 1:200-1:600

Buffer

PBS with 0.02% sodium azide,1% protective protein and 50% glycerol, pH7.4

Shipping Conditions

The product is shipped with ice pack, upon receipt, store it immediately at the temperature recommended.

Storage Conditions

Store at -20°C Valid for 12 months. Avoid freeze / thaw cycles.

Product Datasheet

https://789.bio/ea/8z9ctp

Product MSDS

https://789.bio/eb/OqnH0K

Calculated Molecular Weight

67 kDa

Observed Molecular Weight

72 kDa

Citation 01

https://link.springer.com/article/10.1007/s12035-022-02923-2

Isotype

IgG

Available Sizes

Curated Selection

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