TNF alpha Polyclonal Antibody
Product Specifications
Background
Cytokine that binds to TNFRSF1A/TNFR1 and TNFRSF1B/TNFBR. It is mainly secreted by macrophages and can induce cell death of certain tumor cell lines. It is potent pyrogen causing fever by direct action or by stimulation of interleukin-1 secretion and is implicated in the induction of cachexia, Under certain conditions it can stimulate cell proliferation and induce cell differentiation.
Abbreviation
TNF-α
UniProt
P01375
Host
Rabbit
Reactivity
Human; Mouse; Rat
Immunogen
Synthesized peptide derived from the Internal region of human TNF-α
Target
APC1; APC1 protein; Cachectin; DIF; Differentiation inducing factor; Macrophage cytotoxic factor; Tnf; TNF superfamily; member 2; TNF; macrophage derived; TNF; monocyte derived; TNF-a; TNF-alpha; TNFA; TNFA; TNFSF2; Tumor necrosis factor alpha; Tumor necrosis factor; Tumor necrosis factor ligand superfamily member 2; Tumor Necrosis Factor; Membrane Form; Tumor necrosis factor; soluble form
Clonality
Polyclonal
Conjugation
Unconjugated
Applications
WB; IHC-p; IF
Field of Research
Cancer; Cardiovascular; Metabolism; Immunology; Signal Transduction
Purification
Affinity purification
Concentration
1 mg/mL
Dilution
WB 1:500-1:2000; IHC 1:100-1:300; IF 1:200-1:1000
Buffer
PBS with 0.02% sodium azide, 0.5% protective protein and 50% glycerol, pH7.4
Shipping Conditions
The product is shipped with ice pack, upon receipt, store it immediately at the temperature recommended.
Storage Conditions
Store at -20°C Valid for 12 months. Avoid freeze / thaw cycles.
Calculated Molecular Weight
26kDa
Observed Molecular Weight
16kDa
Citation 01
https://www.nature.com/articles/s41590-022-01166-6
Citation 02
https://academic.oup.com/endo/advance-article-abstract/doi/10.1210/endocr/bqac203/6881427
Isotype
IgG
Available Sizes
Frequently Asked Questions
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