Welcome to GenPrice! Check out our latest updates.

Shopping Cart (0)

Your cart is empty

Add some products to get started!

TGFB1 Polyclonal Antibody

Product Specifications

Background

Multifunctional protein that controls proliferation, differentiation and other functions in many cell types. Many cells synthesize TGFB1 and have specific receptors for it. It positively and negatively regulates many other growth factors. It plays an important role in bone remodeling as it is a potent stimulator of osteoblastic bone formation, causing chemotaxis, proliferation and differentiation in committed osteoblasts. Can promote either T-helper 17 cells (Th17) or regulatory T-cells (Treg) lineage differentiation in a concentration-dependent manner. At high concentrations, leads to FOXP3-mediated suppression of RORC and down-regulation of IL-17 expression, favoring Treg cell development. At low concentrations in concert with IL-6 and IL-21, leads to expression of the IL-17 and IL-23 receptors, favoring differentiation to Th17 cells.

Abbreviation

TGFβ1

UniProt

P01137

Host

Rabbit

Reactivity

Human; Mouse; Rat

Immunogen

Synthesized peptide derived from the C-terminal region of human TGFβ1

Target

Cartilage-inducing factor; CED; Differentiation inhibiting factor; DPD1; LAP; Latency-associated peptide; Prepro transforming growth factor beta 1; TGF beta 1; TGF beta; TGF beta 1 protein; TGF-beta 1 protein; TGF-beta-1; TGF-beta-5; TGF-beta1; TGFB; Tgfb-1; tgfb1; TGFB1; TGFbeta; TGFbeta1; Transforming Growth Factor b1; Transforming Growth Factor beta 1; Transforming growth factor beta 1a; transforming growth factor beta-1; transforming growth factor; beta 1; Transforming Growth Factor-1

Clonality

Polyclonal

Conjugation

Unconjugated

Applications

WB; IHC-p; IF

Field of Research

Cancer; Cardiovascular; Metabolism; Signal Transduction; Stem Cells

Purification

Affinity purification

Concentration

1mg/mL

Dilution

WB 1:500-1:2000; IHC 1:100-1:300; IF 1:200-1:1000

Buffer

PBS with 0.02% sodium azide, 0.5% protective protein and 50% glycerol, pH7.4

Shipping Conditions

The product is shipped with ice pack, upon receipt, store it immediately at the temperature recommended.

Storage Conditions

Store at -20°C Valid for 12 months. Avoid freeze / thaw cycles.

Calculated Molecular Weight

44kDa

Observed Molecular Weight

44kDa

Citation 01

https://www.nature.com/articles/s41467-021-22305-x

Citation 02

https://www.ijbs.com/v19p0204.htm

Citation 03

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8631930/

Citation 04

https://www.nature.com/articles/srep33856

Citation 05

https://www.sciencedirect.com/science/article/pii/S0014299922001923

Citation 06

https://www.frontiersin.org/articles/10.3389/fphys.2020.00403/full?report=reader

Citation 07

https://www.sciencedirect.com/science/article/pii/S0024320517304770

Citation 08

https://www.spandidos-publications.com/10.3892/mmr.2019.10744

Isotype

IgG

Available Sizes

Frequently Asked Questions

More Discoveries

Explore Other Products

Browse additional items from our catalog

BCIP/NBT 1-Component AP Membrane Substrate (SUBB)
6281 100 mL

BCIP/NBT 1-Component AP Membrane Substrate (SUBB)

Sign In for Pricing
View Details
Recombinant Human B4GALT1/GGTB2 Protein (His Tag)
PKSH031198 20 µg

Recombinant Human B4GALT1/GGTB2 Protein (His Tag)

Sign In for Pricing
View Details
Mouse Cdkn1a activation kit by CRISPRa
GA200676 1 Kit

Mouse Cdkn1a activation kit by CRISPRa

Sign In for Pricing
View Details
SPHK2 (N-term) Rabbit Polyclonal Antibody
AP13924PU-N 400 µL

SPHK2 (N-term) Rabbit Polyclonal Antibody

Sign In for Pricing
View Details
PPIAL4G (NM_001123068) Human Over-expression Lysate
LC426600 20 µg

PPIAL4G (NM_001123068) Human Over-expression Lysate

Sign In for Pricing
View Details
Colloidal Gold Conjugated Rabbit Affinity Purified Antibody to Horseradish Peroxidase, 5nm
GM-503-5 1 mL

Colloidal Gold Conjugated Rabbit Affinity Purified Antibody to Horseradish Peroxidase, 5nm

Sign In for Pricing
View Details