TGFB1 Polyclonal Antibody

Product Specifications

Background

Multifunctional protein that controls proliferation, differentiation and other functions in many cell types. Many cells synthesize TGFB1 and have specific receptors for it. It positively and negatively regulates many other growth factors. It plays an important role in bone remodeling as it is a potent stimulator of osteoblastic bone formation, causing chemotaxis, proliferation and differentiation in committed osteoblasts. Can promote either T-helper 17 cells (Th17) or regulatory T-cells (Treg) lineage differentiation in a concentration-dependent manner. At high concentrations, leads to FOXP3-mediated suppression of RORC and down-regulation of IL-17 expression, favoring Treg cell development. At low concentrations in concert with IL-6 and IL-21, leads to expression of the IL-17 and IL-23 receptors, favoring differentiation to Th17 cells.

Abbreviation

TGFβ1

UniProt

P01137

Host

Rabbit

Reactivity

Human; Mouse; Rat

Immunogen

Synthesized peptide derived from the C-terminal region of human TGFβ1

Target

Cartilage-inducing factor; CED; Differentiation inhibiting factor; DPD1; LAP; Latency-associated peptide; Prepro transforming growth factor beta 1; TGF beta 1; TGF beta; TGF beta 1 protein; TGF-beta 1 protein; TGF-beta-1; TGF-beta-5; TGF-beta1; TGFB; Tgfb-1; tgfb1; TGFB1; TGFbeta; TGFbeta1; Transforming Growth Factor b1; Transforming Growth Factor beta 1; Transforming growth factor beta 1a; transforming growth factor beta-1; transforming growth factor; beta 1; Transforming Growth Factor-1

Clonality

Polyclonal

Conjugation

Unconjugated

Applications

WB; IHC-p; IF

Field of Research

Cancer; Cardiovascular; Metabolism; Signal Transduction; Stem Cells

Purification

Affinity purification

Concentration

1mg/mL

Dilution

WB 1:500-1:2000; IHC 1:100-1:300; IF 1:200-1:1000

Buffer

PBS with 0.02% sodium azide, 0.5% protective protein and 50% glycerol, pH7.4

Shipping Conditions

The product is shipped with ice pack, upon receipt, store it immediately at the temperature recommended.

Storage Conditions

Store at -20°C Valid for 12 months. Avoid freeze / thaw cycles.

Calculated Molecular Weight

44kDa

Observed Molecular Weight

44kDa

Citation 01

https://www.nature.com/articles/s41467-021-22305-x

Citation 02

https://www.ijbs.com/v19p0204.htm

Citation 03

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8631930/

Citation 04

https://www.nature.com/articles/srep33856

Citation 05

https://www.sciencedirect.com/science/article/pii/S0014299922001923

Citation 06

https://www.frontiersin.org/articles/10.3389/fphys.2020.00403/full?report=reader

Citation 07

https://www.sciencedirect.com/science/article/pii/S0024320517304770

Citation 08

https://www.spandidos-publications.com/10.3892/mmr.2019.10744

Isotype

IgG

Available Sizes

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