E-Cadherin Polyclonal Antibody

Product Specifications

Background

This gene is a classical cadherin from the cadherin superfamily. The encoded protein is a calcium dependent cell-cell adhesion glycoprotein comprised of five extracellular cadherin repeats, a transmembrane region and a highly conserved cytoplasmic tail. Mutations in this gene are correlated with gastric, breast, colorectal, thyroid and ovarian cancer. Loss of function is thought to contribute to progression in cancer by increasing proliferation, invasion, and/or metastasis. The ectodomain of this protein mediates bacterial adhesion to mammalian cells and the cytoplasmic domain is required for internalization. Identified transcript variants arise from mutation at consensus splice sites.

Abbreviation

E-cadherin

UniProt

P12830

Host

Rabbit

Reactivity

Human

Immunogen

Synthesized peptide derived from the N-terminal region of human E-cadherin

Target

Arc 1; CADH1; Cadherin 1; cadherin 1 type 1 E-cadherin; Cadherin1; CAM 120/80; CD 324; CD324; CD324 antigen; cdh1; CDHE; E-Cad/CTF3; E-cadherin; ECAD; Epithelial cadherin; epithelial calcium dependant adhesion protein; LCAM; Liver cell adhesion molecule; UVO; Uvomorulin

Clonality

Polyclonal

Conjugation

Unconjugated

Applications

WB; IHC-p; IF

Field of Research

Cancer; Developmental Biology; Signal Transduction

Purification

Affinity purification

Concentration

1 mg/mL

Dilution

WB 1:500-1:2000; IHC 1:100-1:300; IF 1:200-1:1000

Buffer

PBS with 0.02% sodium azide, 0.5% protective protein and 50% glycerol, pH7.4

Shipping Conditions

The product is shipped with ice pack, upon receipt, store it immediately at the temperature recommended.

Storage Conditions

Store at -20°C Valid for 12 months. Avoid freeze / thaw cycles.

Calculated Molecular Weight

97kDa

Observed Molecular Weight

100kDa

Citation 01

https://europepmc.org/article/pmc/pmc8712759?javascript_support=no

Citation 02

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8068511/

Citation 03

https://www.nature.com/articles/srep33856

Citation 04

https://www.hindawi.com/journals/cjgh/2022/5332129/

Citation 05

https://www.spandidos-publications.com/10.3892/ol.2018.9251?text=abstract

Citation 06

https://www.spandidos-publications.com/10.3892/mmr.2021.12471

Citation 07

https://www.ncbi.nlm.nih.gov/pmc/articles/pmc8607078/

Isotype

IgG

Available Sizes

Curated Selection

Explore Other Products

Discover premium biology products from our extensive collection of 20M+ items

A11559-100UG 100 µg

ABCC9 Antibody, Biotin conjugated

Ask

View Details

D8916 96 Tests

GTPase IMAP family member 5 (GIMAP5) Mouse ELISA Kit

Ask

View Details

MBS1348304-01 0.02 mg (E-Coli)

Recombinant Staphylococcus aureus ATP synthase subunit delta (atpH)

Ask

View Details

MBS1348304-02 0.1 mg (E-Coli)

Recombinant Staphylococcus aureus ATP synthase subunit delta (atpH)

Ask

View Details

MBS1348304-03 0.02 mg (Yeast)

Recombinant Staphylococcus aureus ATP synthase subunit delta (atpH)

Ask

View Details

MBS1348304-04 0.1 mg (Yeast)

Recombinant Staphylococcus aureus ATP synthase subunit delta (atpH)

Ask

View Details