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Cleaved-PARP1 (D214) Polyclonal Antibody

Product Specifications

Background

This gene encodes a chromatin-associated enzyme, poly (ADP-ribosyl) transferase, which modifies various nuclear proteins by poly (ADP-ribosyl) ation. The modification is dependent on DNA and is involved in the regulation of various important cellular processes such as differentiation, proliferation, and tumor transformation and also in the regulation of the molecular events involved in the recovery of cell from DNA damage. In addition, this enzyme may be the site of mutation in Fanconi anemia, and may participate in the pathophysiology of type I diabetes.

Abbreviation

Cleaved-PARP1 (D214)

UniProt

P09874

Host

Rabbit

Reactivity

Human; Mouse

Immunogen

Synthesized peptide derived from the Internal region of human PARP-1

Target

ADP-ribosyltransferase diphtheria toxin-like 1; ADPRT 1; ADPRT; ADPRT1; APOPAIN; ARTD1; NAD (+) ADP-ribosyltransferase 1; PARP; PARP-1; PARP1; PARP1; Poly [ADP-ribose] polymerase 1; Poly ADP ribose polymerase 1; Poly[ADP-ribose] synthase 1; PPOL; SCA1

Clonality

Polyclonal

Conjugation

Unconjugated

Applications

WB; IHC-p; IF

Field of Research

Cancer; Cell Biology; Epigenetics and Nuclear Signaling; Metabolism

Purification

Affinity purification

Concentration

1 mg/mL

Dilution

WB 1:500-2000; IHC 1:50-300; IF 1:50-300

Buffer

PBS with 0.02% sodium azide, 0.5% protective protein and 50% glycerol, pH7.4

Shipping Conditions

The product is shipped with ice pack, upon receipt, store it immediately at the temperature recommended.

Storage Conditions

Store at -20°C Valid for 12 months. Avoid freeze / thaw cycles.

Product Datasheet

https://789.bio/ea/t9v5ck

Product MSDS

https://789.bio/eb/WT8WT8

Calculated Molecular Weight

113kDa

Observed Molecular Weight

24kDa

Citation 01

https://onlinelibrary.wiley.com/doi/abs/10.1002/tox.23749

Citation 02

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7485694/

Isotype

IgG

Available Sizes

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