Cleaved-PARP1 (D214) Polyclonal Antibody
Product Specifications
Background
This gene encodes a chromatin-associated enzyme, poly (ADP-ribosyl) transferase, which modifies various nuclear proteins by poly (ADP-ribosyl) ation. The modification is dependent on DNA and is involved in the regulation of various important cellular processes such as differentiation, proliferation, and tumor transformation and also in the regulation of the molecular events involved in the recovery of cell from DNA damage. In addition, this enzyme may be the site of mutation in Fanconi anemia, and may participate in the pathophysiology of type I diabetes.
Abbreviation
Cleaved-PARP1 (D214)
UniProt
P09874
Host
Rabbit
Reactivity
Human; Mouse
Immunogen
Synthesized peptide derived from the Internal region of human PARP-1
Target
ADP-ribosyltransferase diphtheria toxin-like 1; ADPRT 1; ADPRT; ADPRT1; APOPAIN; ARTD1; NAD (+) ADP-ribosyltransferase 1; PARP; PARP-1; PARP1; PARP1; Poly [ADP-ribose] polymerase 1; Poly ADP ribose polymerase 1; Poly[ADP-ribose] synthase 1; PPOL; SCA1
Clonality
Polyclonal
Conjugation
Unconjugated
Applications
WB; IHC-p; IF
Field of Research
Cancer; Cell Biology; Epigenetics and Nuclear Signaling; Metabolism
Purification
Affinity purification
Concentration
1 mg/mL
Dilution
WB 1:500-2000; IHC 1:50-300; IF 1:50-300
Buffer
PBS with 0.02% sodium azide, 0.5% protective protein and 50% glycerol, pH7.4
Shipping Conditions
The product is shipped with ice pack, upon receipt, store it immediately at the temperature recommended.
Storage Conditions
Store at -20°C Valid for 12 months. Avoid freeze / thaw cycles.
Calculated Molecular Weight
113kDa
Observed Molecular Weight
24kDa
Citation 01
https://onlinelibrary.wiley.com/doi/abs/10.1002/tox.23749
Citation 02
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7485694/
Isotype
IgG
Available Sizes
Curated Selection
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