Cleaved-CASP3 p12 (D175) Polyclonal Antibody

Product Specifications

Background

Involved in the activation cascade of caspases responsible for apoptosis execution. At the onset of apoptosis it proteolytically cleaves poly (ADP-ribose) polymerase (PARP) at a '216-Asp-Gly-217' bond. Cleaves and activates sterol regulatory element binding proteins (SREBPs) between the basic helix-loop-helix leucine zipper domain and the membrane attachment domain. Cleaves and activates caspase-6, -7 and -9. Involved in the cleavage of huntingtin.

Abbreviation

Cleaved-Caspase-3 p12 (D175)

UniProt

P42574

Host

Rabbit

Reactivity

Human

Immunogen

Synthesized peptide derived from the Internal region of human Caspase-3 p12

Target

A830040C14Rik; Apopain; CASP-3; CASP3; CASP3; Casp3a; Caspase 3; Caspase 3; apoptosis-related cysteine peptidase; Caspase 3; apoptosis-related cysteine protease; Caspase 3; apoptosis-related cysteine protease a; Caspase-3 subunit p12; CC3; CPP-32; CPP32; CPP32B; Cysteine protease CPP32; EC 3.4.22.56; LICE; mldy; OTTHUMP00000165052; OTTHUMP00000165053; OTTHUMP00000165054; PARP cleavage protease; Procaspase3; Protein Yama; SCA 1; SCA-1; SREBP cleavage activity 1; Yama

Clonality

Polyclonal

Conjugation

Unconjugated

Applications

WB; IHC-p; IF

Field of Research

Cancer; Cell Biology; Metabolism; Neuroscience

Purification

Affinity purification

Concentration

1mg/mL

Dilution

WB 1:500-2000; IHC 1:50-300; IF 1:50-300

Buffer

PBS with 0.02% sodium azide, 0.5% protective protein and 50% glycerol, pH7.4

Shipping Conditions

The product is shipped with ice pack, upon receipt, store it immediately at the temperature recommended.

Storage Conditions

Store at -20°C Valid for 12 months. Avoid freeze / thaw cycles.

Calculated Molecular Weight

32kDa

Observed Molecular Weight

20+35kDa

Citation 01

https://www.nature.com/articles/s41590-022-01166-6

Citation 02

https://static.frontiersin.org/articles/10.3389/fmolb.2022.816510/full

Citation 03

https://www.frontiersin.org/articles/10.3389/fphar.2021.646953/full?utm_source=S-TWT&utm_medium=SNET&utm_campaign=ECO_FPHAR_XXXXXXXX_auto-dlvrit

Citation 04

https://www.worldscientific.com/doi/abs/10.1142/S0192415X21500245

Citation 05

https://www.sciencedirect.com/science/article/pii/S094471131630191X

Isotype

IgG

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