STL127705

STL127705 (Compound L) is a potent Ku 70/80 heterodimer protein inhibitor with an IC50 of 3.5 μM. STL127705 interferes the binding of Ku70/80 to DNA and by inhibits the activation of the DNA-PKCS kinase. STL127705 shows antiproliferative and anticancer activity. STL127705 induces apoptosis[1][2].

Product Specifications

CAS Number

[1326852-06-5]

UNSPSC

12352005

Hazard Statement

H315, H319, H320

Target

Apoptosis; DNA-PK

Type

Reference compound

Related Pathways

Apoptosis; Cell Cycle/DNA Damage; PI3K/Akt/mTOR

Applications

Cancer-Kinase/protease

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/stl127705.html

Purity

98.97

Solubility

DMSO : < 1 mg/mL|H2O : < 0.1 mg/mL (ultrasonic)

Smiles

O=C1NC2=NC(NCCC3=CC=C(OC)C(OC)=C3)=NC=C2C(N1C4=CC=CC(F)=C4)=O

Molecular Formula

C22H20FN5O4

Molecular Weight

437.42

Precautions

H315, H319, H320

References & Citations

[1]Weterings E, et al. A novel small molecule inhibitor of the DNA repair protein Ku70/80. DNA Repair (Amst) . 2016 Jul;43:98-106.|[2]Guo N, et al. Inhibiting nonhomologous end-joining repair would promote the antitumor activity of gemcitabine in nonsmall cell lung cancer cell lines. Anticancer Drugs. 2022 Jun 1;33 (5) :502-508.