CASP3 Monoclonal Antibody

Product Specifications

Background

Involved in the activation cascade of caspases responsible for apoptosis execution. At the onset of apoptosis it proteolytically cleaves poly (ADP-ribose) polymerase (PARP) at a '216-Asp-Gly-217' bond. Cleaves and activates sterol regulatory element binding proteins (SREBPs) between the basic helix-loop-helix leucine zipper domain and the membrane attachment domain. Cleaves and activates caspase-6, -7 and -9. Involved in the cleavage of huntingtin.

Abbreviation

CASP3

UniProt

P42574

Host

Mouse

Reactivity

Human; Mouse; Rat

Immunogen

Synthetic Peptide of Caspase-3

Target

A830040C14Rik; Apopain; CASP-3; CASP3; CASP3; Casp3a; Caspase 3; Caspase 3; apoptosis-related cysteine peptidase; Caspase 3; apoptosis-related cysteine protease; Caspase 3; apoptosis-related cysteine protease a; Caspase-3 subunit p12; CC3; CPP-32; CPP32; CPP32B; Cysteine protease CPP32; EC 3.4.22.56; LICE; mldy; OTTHUMP00000165052; OTTHUMP00000165053; OTTHUMP00000165054; PARP cleavage protease; Procaspase3; Protein Yama; SCA 1; SCA-1; SREBP cleavage activity 1; Yama

Clonality

Monoclonal

Clone

Clone:4B8

Conjugation

Unconjugated

Applications

IHC-p

Field of Research

Cancer; Cell Biology; Metabolism; Neuroscience

Purification

Protein A purification

Concentration

1 mg/mL

Dilution

IHC 1:100-200

Buffer

PBS with 0.02% sodium azide, 0.5% protective protein and 50% glycerol, pH7.4

Shipping Conditions

The product is shipped with ice pack, upon receipt, store it immediately at the temperature recommended.

Storage Conditions

Store at -20°C Valid for 12 months. Avoid freeze / thaw cycles.

Citation 01

https://www.sciencedirect.com/science/article/pii/S0753332220302663

Isotype

IgG

Available Sizes

Curated Selection

Explore Other Products

Discover premium biology products from our extensive collection of 20M+ items

FAB8110JF525 0.1 mL

Mouse Monoclonal CXCR2/IL-8RB Antibody (866614) [Janelia Fluor 525]

Ask

View Details

RC208625L4V 200 µL

SLC37A2 (NM_198277) Human Tagged ORF Clone Lentiviral Particle

Ask

View Details

N5376-99C 2 mL

NP (4-Hydroxy-3-nitrophenylacetyl) discontinued

Ask

View Details

RC207046L4V 200 µL

MMGT1 (NM_173470) Human Tagged ORF Clone Lentiviral Particle

Ask

View Details