SGK1 Monoclonal Antibody
Product Specifications
Background
Protein kinase that plays an important role in cellular stress response. Activates certain potassium, sodium, and chloride channels, suggesting an involvement in the regulation of processes such as cell survival, neuronal excitability and renal sodium excretion. Sustained high levels and activity may contribute to conditions such as hypertension and diabetic nephropathy. Mediates cell survival signals, phosphorylates and negatively regulates pro-apoptotic FOXO3A. Phosphorylates NEDD4L, which leads to its inactivation and to the subsequent activation of various channels and transporters such as ENaC, KCNA3/Kv1.3 or EAAT1. Isoform 2 exhibited a greater effect on cell plasma membrane expression of ENaC and Na (+) transport than isoform 1.
Abbreviation
SGK1 Mouse (4D12)
UniProt
O00141
Host
Mouse
Reactivity
Human; Mouse; Rat
Immunogen
Synthetic Peptide of SGK1
Target
OTTHUMP00000017247; Serine/threonine protein kinase SGK; Serine/threonine protein kinase Sgk1; Serine/threonine-protein kinase Sgk1; Serum and glucocorticoid regulated kinase; Serum/glucocorticoid regulated kinase 1; Serum/glucocorticoid regulated kinase; Serum/glucocorticoid-regulated kinase 1; SGK 1; SGK; SGK1; Sgk1 variant i3; SGK1
Clonality
Monoclonal
Clone
Clone:4D12
Conjugation
Unconjugated
Applications
IHC-p
Field of Research
Cancer; Developmental Biology; Signal Transduction; Stem Cells
Purification
Protein A purification
Concentration
1 mg/mL
Dilution
IHC 1:100-200
Buffer
PBS with 0.02% sodium azide, 0.5% protective protein and 50% glycerol, pH7.4
Shipping Conditions
The product is shipped with ice pack, upon receipt, store it immediately at the temperature recommended.
Storage Conditions
Store at -20°C Valid for 12 months. Avoid freeze / thaw cycles.
Product Datasheet
https://789.bio/ea/yd88ok
Product MSDS
https://789.bio/eb/jDefHC
Isotype
IgG
Available Sizes
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