BAX Monoclonal Antibody
Product Specifications
Background
Accelerates programmed cell death by binding to, and antagonizing the apoptosis repressor BCL2 or its adenovirus homolog E1B 19k protein. Under stress conditions, undergoes a conformation change that causes translocation to the mitochondrion membrane, leading to the release of cytochrome c that then triggers apoptosis. Promotes activation of CASP3, and thereby apoptosis.
Abbreviation
BAX
UniProt
Q07812
Host
Mouse
Reactivity
Human; Mouse; Rat
Immunogen
Synthetic Peptide of Bax
Target
Apoptosis regulator BAX; BAX; Bax-protein; BAX; BAXA; Baxdelta2G9; Baxdelta2G9omega; Baxdelta2omega; Bcl-2-like protein 4; BCL2 associated X protein; BCL2 associated X protein omega; BCL2 associated X protein transcript variant delta2; Bcl2-L-4; BCL2L4; membrane isoform alpha
Clonality
Monoclonal
Clone
Clone:1D8
Conjugation
Unconjugated
Applications
WB; IHC-p
Field of Research
Cancer; Cell Biology; Metabolism
Purification
Protein A purification
Concentration
1 mg/mL
Dilution
WB 1:1000-2000; IHC 1:100-200
Buffer
PBS with 0.02% sodium azide, 0.5% protective protein and 50% glycerol, pH7.4
Shipping Conditions
The product is shipped with ice pack, upon receipt, store it immediately at the temperature recommended.
Storage Conditions
Store at -20°C Valid for 12 months. Avoid freeze / thaw cycles.
Observed Molecular Weight
20kDa
Citation 01
https://www.sciencedirect.com/science/article/pii/S0168822722008804
Citation 02
https://link.springer.com/article/10.1007/s11356-023-25636-y
Citation 03
https://bmccomplementmedtherapies.biomedcentral.com/articles/10.1186/s12906-019-2768-1
Isotype
IgG
Available Sizes
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