Active CASP3 Monoclonal Antibody

Product Specifications

Background

Involved in the activation cascade of caspases responsible for apoptosis execution. At the onset of apoptosis it proteolytically cleaves poly (ADP-ribose) polymerase (PARP) at a '216-Asp-Gly-217' bond. Cleaves and activates sterol regulatory element binding proteins (SREBPs) between the basic helix-loop-helix leucine zipper domain and the membrane attachment domain. Cleaves and activates caspase-6, -7 and -9. Involved in the cleavage of huntingtin.

Abbreviation

Active Caspase-3

UniProt

P42574

Host

Mouse

Reactivity

Human; Mouse; Rat

Immunogen

Recombinant Protein

Target

A830040C14Rik; Apopain; CASP-3; CASP3; CASP3; Casp3a; Caspase 3; Caspase 3; apoptosis-related cysteine peptidase; Caspase 3; apoptosis-related cysteine protease; Caspase 3; apoptosis-related cysteine protease a; Caspase-3 subunit p12; CC3; CPP-32; CPP32; CPP32B; Cysteine protease CPP32; EC 3.4.22.56; LICE; mldy; OTTHUMP00000165052; OTTHUMP00000165053; OTTHUMP00000165054; PARP cleavage protease; Procaspase3; Protein Yama; SCA 1; SCA-1; SREBP cleavage activity 1; Yama

Clonality

Monoclonal

Clone

Clone:5A2

Conjugation

Unconjugated

Applications

WB; IHC-p; IF

Field of Research

Cancer; Cell Biology; Metabolism; Neuroscience

Purification

Protein A purification

Concentration

1 mg/mL

Dilution

WB 1:500-1:1000; IHC 1:100-1:200; IF 1:100-1:200

Buffer

PBS with 0.02% sodium azide and 50% glycerol pH 7.4.

Shipping Conditions

The product is shipped with ice pack, upon receipt, store it immediately at the temperature recommended.

Storage Conditions

Store at -20°C Valid for 12 months. Avoid freeze / thaw cycles.

Observed Molecular Weight

17kDa

Citation 01

https://www.sciencedirect.com/science/article/pii/S2162253122003006

Citation 02

https://www.mdpi.com/1806946

Citation 03

https://pubs.rsc.org/en/content/articlelanding/2021/fo/d1fo01547h

Citation 04

https://www.sciencedirect.com/science/article/pii/S1382668920300880

Citation 05

https://www.sciencedirect.com/science/article/pii/S0161813X18304170

Citation 06

https://www.spandidos-publications.com/10.3892/ol.2018.9635?text=abstract

Citation 07

https://link.springer.com/article/10.1134/S0022093021060120

Isotype

IgG

Available Sizes

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