Catenin beta Monoclonal Antibody
Product Specifications
Background
Key dowstream component of the canonical Wnt signaling pathway. In the absence of Wnt, forms a complex with AXIN1, AXIN2, APC, CSNK1A1 and GSK3B that promotes phosphorylation on N-terminal Ser and Thr residues and ubiquitination of CTNNB1 via BTRC and its subsequent degradation by the proteasome. In the presence of Wnt ligand, CTNNB1 is not ubiquitinated and accumulates in the nucleus, where it acts as a coactivator for transcription factors of the TCF/LEF family, leading to activate Wnt responsive genes.Involved in the regulation of cell adhesion. The majority of beta-catenin is localized to the cell membrane and is part of E-cadherin/catenin adhesion complexes which are proposed to couple cadherins to the actin cytoskeleton.
Abbreviation
Catenin-β
UniProt
P35222
Host
Mouse
Reactivity
Human; Mouse; Rat
Immunogen
Recombinant Protein
Target
Beta catenin; Beta-catenin; Cadherin associated protein; Catenin (cadherin associated protein) ; beta 1;88kDa; Catenin beta 1; Catenin beta-1; CATNB; CHBCAT; CTNB1; CTNNB; CTNNB1; DKFZp686D02253; FLJ25606; FLJ37923; OTTHUMP00000162082; OTTHUMP00000165222; OTTHUMP00000165223; OTTHUMP00000209288; OTTHUMP00000209289
Clonality
Monoclonal
Clone
Clone:2E4
Conjugation
Unconjugated
Applications
WB; IHC-p; IF
Field of Research
Cancer; Cardiovascular; Neuroscience; Signal Transduction; Stem Cells
Purification
Protein A purification
Concentration
1 mg/mL
Dilution
WB 1:500-1:2000; IHC 1:100-1:300; IF 1:100-1:300
Buffer
PBS with 0.02% sodium azide and 50% glycerol pH 7.4.
Shipping Conditions
The product is shipped with ice pack, upon receipt, store it immediately at the temperature recommended.
Storage Conditions
Store at -20°C Valid for 12 months. Avoid freeze / thaw cycles.
Observed Molecular Weight
92kDa
Citation 01
https://www.frontiersin.org/articles/10.3389/fonc.2021.669560/full
Isotype
IgG
Available Sizes
Curated Selection
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