XRCC4 Monoclonal Antibody
Product Specifications
Background
Involved in DNA non-homologous end joining (NHEJ) required for double-strand break repair and V (D) J recombination. Binds to DNA and to DNA ligase IV (LIG4) . The LIG4-XRCC4 complex is responsible for the NHEJ ligation step, and XRCC4 enhances the joining activity of LIG4. Binding of the LIG4-XRCC4 complex to DNA ends is dependent on the assembly of the DNA-dependent protein kinase complex DNA-PK to these DNA ends.
Abbreviation
XRCC4
UniProt
Q13426
Host
Mouse
Reactivity
Human
Immunogen
Synthetic Peptide
Target
DNA double strand break repair and V (D) J recombination protein XRCC4; DNA repair protein XRCC4; SSMED; X ray repair complementing defective repair in Chinese hamster cells 4; X ray repair cross complementing 4; X ray repair cross complementing protein 4; X-ray repair cross-complementing protein 4; XRCC 4; XRCC4; XRCC4
Clonality
Monoclonal
Clone
Clone:8K2
Conjugation
Unconjugated
Applications
WB; IHC-p; IF; IP
Field of Research
Cancer; Epigenetics and Nuclear Signaling
Purification
Protein A purification
Concentration
1 mg/mL
Dilution
WB 1:500-1:2000; IHC 1:50-300; IF 1:50-1:200; IP 1:100-1:300
Buffer
PBS with 0.02% sodium azide and 50% glycerol pH 7.4.
Shipping Conditions
The product is shipped with ice pack, upon receipt, store it immediately at the temperature recommended.
Storage Conditions
Store at -20°C Valid for 12 months. Avoid freeze / thaw cycles.
Calculated Molecular Weight
38kDa
Observed Molecular Weight
38kDa
Isotype
IgG
Available Sizes
Curated Selection
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