Phospho-SMAD2/3 (Thr8) Polyclonal Antibody

Product Specifications

Background

SMAD is a family of proteins similar to the gene products of the Drosophila gene 'mothers against decapentaplegic' (Mad) and the C. elegans gene Sma. SMAD proteins are signal transducers and transcriptional modulators that mediate multiple signaling pathways. They mediate the signal of the transforming growth factor (TGF) -beta, and thus regulate multiple cellular processes, such as cell proliferation, apoptosis, and differentiation.

Abbreviation

Smad2/3 (phospho Thr8)

UniProt

Q15796, P84022

Host

Rabbit

Reactivity

Human; Mouse; Rat

Immunogen

Synthesized peptide derived from human Smad2/3 around the phosphorylation site of Thr8

Target

SMAD2; MADH2; MADR2; Mothers against decapentaplegic homolog 2; MAD homolog 2; Mothers against DPP homolog 2; JV18-1; Mad-related protein 2; hMAD-2; SMAD family member 2; SMAD 2; Smad2; hSMAD2; SMAD3; MADH3; Mothers against decapentaplegic

Clonality

Polyclonal

Conjugation

Unconjugated

Applications

Field of Research

Cancer; Epigenetics and Nuclear Signaling; Signal Transduction; Stem Cells

Purification

Affinity purification

Concentration

1 mg/mL

Dilution

WB 1:500-1:2000

Buffer

PBS with 0.02% sodium azide, 0.5% protective protein and 50% glycerol, pH7.4

Shipping Conditions

The product is shipped with ice pack, upon receipt, store it immediately at the temperature recommended.

Storage Conditions

Store at -20°C Valid for 12 months. Avoid freeze / thaw cycles.

Calculated Molecular Weight

48kDa

Observed Molecular Weight

48kDa

Citation 01

https://www.nature.com/articles/s41590-022-01166-6

Citation 02

https://www.mdpi.com/1333040

Citation 03

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9006815/

Citation 04

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8631930/

Citation 05

https://www.sciencedirect.com/science/article/pii/S0024320521006895

Citation 06

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9827317/

Citation 07

https://www.frontiersin.org/articles/10.3389/fphys.2020.00403/full?report=reader

Isotype

IgG

Available Sizes

Curated Selection

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